Carboprost methylate
Carboprost methylate
CAS: 62776-96-9
Molecular Formula: C22H38O5
Carboprost methylate - Names and Identifiers
Carboprost methylate - Physico-chemical Properties
| Molecular Formula | C22H38O5 |
| Molar Mass | 382.54 |
| Density | 1.096±0.06 g/cm3(Predicted) |
| Boling Point | 501.7±50.0 °C(Predicted) |
| pKa | 14.66±0.29(Predicted) |
| Use | Prostaglandin drugs for termination of early pregnancy, mid-term labor induction, etc |
Carboprost methylate - Standard
Authoritative Data Verified Data
This product is (Z)-7-[(lR, 2R,3R, 5S)-3, 5-dihydroxy-2-[(E)-(3S)-3-methyl-1-octene-3-hydroxy] cyclopentyl]-5-heptanoic acid methyl ester. Calculated as dried product, the content of C22H38O5 shall not be less than 91.0%.
Last Update：2024-01-02 23:10:35
Carboprost methylate - Trait
Authoritative Data Verified Data
- This product is white to light yellow solid.
- This product is soluble in ether or ethanol, slightly soluble in water.
Last Update：2022-01-01 11:37:08
Carboprost methylate - Differential diagnosis
Authoritative Data Verified Data
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 98).
Last Update：2022-01-01 11:37:08
Carboprost methylate - Exam
Authoritative Data Verified Data
15-episomer
take this product, add methylated solution and dilute to make a solution containing about 0.2mg per lml as a test solution; Take 2ml for precision measurement and put it in a 50ml measuring flask, as a control solution, it was diluted to the scale with methanol and shaken. According to the chromatographic conditions under the item of Holter determination, 20 u1 of the test solution and the control solution are respectively injected into the liquid chromatograph, and the chromatogram is recorded to 2 times of the retention time of the main component peak. If there are 15-episomer chromatographic peaks corresponding to those in the test solution for system suitability in the chromatogram of the test solution, the peak area shall not be greater than that of the main peak area of the control solution (4.0%).
loss on drying
take this product, put it in a phosphorus pentoxide dryer, and dry it under reduced pressure for 24 hours. The weight loss shall not exceed 3.0% (General rule 0831).
Last Update：2022-01-01 11:37:09
Carboprost methylate - Content determination
Authoritative Data Verified Data
measured by high performance liquid chromatography (General rule still 12).
chromatographic conditions and system suitability test
with eighteen alkyl silane bonded silica gel as the filler; Methanol-water (70:30) as the mobile phase; The detection wavelength was 202 nm, dissolving and diluting the fermentation broth to make a solution containing about 0.2mg of each 15-episomer and carboprost methyl ester in 1 ml, as the system suitability test solution, taking 20u1 injection human liquid chromatograph, the theoretical plate number is not less than 2000 calculated by the carboprost methyl ester peak, and the separation degree between the 15-episomer peak and the carboprost methyl ester peak should be greater than 1.2.
assay
take an appropriate amount of this product, weigh it accurately, dissolve it with fermentation and dilute it quantitatively to make a solution containing 0.2mg per 1 ml, and use it as a sample solution, and take 20ul for precision measurement, inject into liquid chromatograph, record the chromatogram; Take the carboprost methyl ester reference substance, with the same method, according to the external standard method to calculate the peak area, obtained.
Last Update：2022-01-01 11:37:10
Carboprost methylate - Category
Authoritative Data Verified Data
prostaglandins.
Last Update：2022-01-01 11:37:10
Carboprost methylate - Storage
Authoritative Data Verified Data
shading, sealing, low temperature (below -5°C) storage.
Last Update：2022-01-01 11:37:10
Carboprost methylate - Carboprost Methylate Suppositories
Authoritative Data Verified Data
This product contains carboprost methyl ester (C22H38O5) should be 90.0% ~ 110.0% of the label amount.
trait
This product is milky white to light yellow suppository.
identification
In the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the control solution.
examination
should comply with the relevant provisions under suppository (General rule 0107).
Content determination
Take 10 capsules of this product, precise weighing, let them grind in an onyx mortar, weigh an appropriate amount (about 2mg equivalent to carboprost methyl ester) precisely, and put them in a sealed Erlenmeyer flask, add methylated 10ml accurately, plug, place in water bath at 45°C, sonicate for about 3 minutes to dissolve methyl carboprost, take it out, put it in ice bath, and centrifuge it after the matrix solidifies, put it to room temperature, take the solution as a test solution, and take 20 u1 for precision children, and measure it according to the method under the item of determination of carprost nail content.
category
methyl isocarboprost.
specification
(1)0.5mg (2)lmg
storage
shading, closed, low temperature (less than a 5°C) storage.
Last Update：2022-01-01 11:37:11
Supplier List
Spot supply
Product Name: Carboprost Trometamol Impurity 13 Visit Supplier Webpage Request for quotationCAS: 62776-96-9
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: Carboprost Trometamol Impurity 13 Visit Supplier Webpage Request for quotationCAS: 62776-96-9
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
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